By Jacqueline A. Hubbard,Devin K. Binder
Epilepsy is a devastating crew of neurological issues characterised by way of periodic and unpredictable seizure task within the mind. there's a serious desire for brand spanking new medicinal drugs and techniques given than at the very least one-third of all epilepsy sufferers aren't made freed from seizures through latest drugs and develop into "medically refractory". a lot of epilepsy learn has thinking about neuronal healing objectives, yet present antiepileptic medications usually reason critical cognitive, developmental, and behavioral unwanted effects. fresh findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure task. moreover, many vital mobile and molecular adjustments ensue in astrocytes in epileptic tissue in either people and animal versions of epilepsy. The objective of Astrocytes and Epilepsy is to comprehensively overview intriguing findings linking alterations in astrocytes to useful alterations accountable for epilepsy for the 1st time in e-book layout. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes may perhaps symbolize a major new healing aim within the keep watch over of epilepsy.
Astrocytes and Epilepsy contains historical past explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and proof from either human tissue reports and animal types linking useful adjustments in astrocytes to epilepsy. superbly labelled diagrams are awarded and proper figures from the literature are reproduced to explain key findings and ideas during this swiftly rising box. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.
- Presents the 1st entire publication to synthesize old and up to date examine on astrocytes and epilepsy into one coherent volume
- Provides a good source at the box of astrocyte biology and astrocyte-neuron interactions
- Details strength healing goals, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
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